Which enzyme(s) is/are responsible for the following reaction? Pyruvate + CoA + NAD⁺ → Acetyl CoA + NADH + H⁺ + CO₂ A) acetyl CoA synthetase B) pyruvate decarboxylase C) pyruvate dehydrogenase complex D) A and B E) A, B, and C

Question

Quizplus · Accepted Answer

The reaction given in the question is a key step in the process of aerobic respiration, which occurs in mitochondria. The enzyme complex responsible for this reaction is the pyruvate dehydrogenase complex (PDC), which is composed of multiple enzymes and coenzymes, including pyruvate decarboxylase (B) and acetyl CoA synthetase (A). However, since the question specifically asks for the enzyme(s) responsible for the given reaction, and not for the entire PDC complex, the best answer is C, which correctly identifies the PDC complex as a whole. Therefore, choice C is the best choice.

Which Enzyme(s) Is/are Responsible for the Following Reaction? Pyruvate