Which of the following functions as a "flexible swinging arm" when it transfers the reaction intermediate from one active site to the next? A) FAD B) NAD⁺ C) lipoamide D) thiamine pyrophosphate E) coenzyme A

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Quizplus · Accepted Answer

Lipoamide, also known as lipoic acid, functions as a flexible swinging arm when it transfers the reaction intermediate between the active sites of enzymes in the pyruvate dehydrogenase complex, alpha-ketoglutarate dehydrogenase complex, and branched-chain alpha-keto acid dehydrogenase complex. This flexible swinging arm allows the intermediates to be channeled between the different active sites without the need for release into the bulk solvent. The other choices (FAD, NAD+, thiamine pyrophosphate, and coenzyme A) do not function as flexible swinging arms.

Which of the Following Functions as a "Flexible Swinging Arm