How do coactivators mediate expression?
A) by blocking RNA polymerase binding
B) by loosening the histone complex formation
C) by inhibiting intron splicing
D) A and B
E) B and C

Question

Quizplus · Accepted Answer

Coactivators bind to specific regions of DNA and interact with histones, causing them to become more accessible to transcription factors and RNA polymerase, thus increasing gene expression. This is achieved through the loosening of the histone complex formation, form of chromatin modification. Coactivators do not inhibit RNA polymerase binding, nor do they inhibit intron splicing, both of which would decrease gene expression.

How Do Coactivators Mediate Expression