In transcription, the 3`-hydroxyl group: A) attacks the α-phosphorous group on an incoming nucleotide. B) binds to a Mg⁺²in the active site. C) binds to the 5` ribose. D) attacks the 5` hydrogen of the incoming nucleotide. E) None of the above.

Question

Quizplus · Accepted Answer

The 3`-hydroxyl group on the growing RNA chain attacks the ɑ-phosphorous group on the incoming nucleotide during transcription elongation, forming a new phosphodiester bond and extending the RNA chain. This reaction is catalyzed by RNA polymerase.

In Transcription, the 3`-Hydroxyl Group