The competitive inhibitor(s) of dihydrofolate reductase is/are:

Question

Quizplus · Accepted Answer

Both aminopterin and methotrexate are competitive inhibitors of dihydrofolate reductase, as both drugs bind to the active site of the enzyme and block the binding of the natural substrate, dihydrofolate. Fluorouracil acts as an antimetabolite by inhibiting thymidylate synthase, which is downstream of dihydrofolate reductase in the nucleotide biosynthesis pathway, but it is not a competitive inhibitor of dihydrofolate reductase.

The Competitive Inhibitor(s) of Dihydrofolate Reductase Is/are