Succinate dehydrogenase deficiency or genetic mutation results in:
A) cancer through HIF-1.
B) decreased rate of gylcolysis.
C) depletion of succinate in mitochondria.
D) A and B.
E) A, B, and C.

Question

Quizplus · Accepted Answer

Succinate dehydrogenase deficiency or genetic mutation results in accumulation of succinate in mitochondria, which leads to stabilization of HIF-1 (hypoxia inducible factor 1). HIF-1 then triggers the expression of genes associated with cancer, such as angiogenesis and glucose metabolism.

Succinate Dehydrogenase Deficiency or Genetic Mutation Results In