Pyruvate is decarboxylated by which subunit of the PDH? A) E₁ B) E₂ C) E₃ D) E₄ E) E₅

Question

Quizplus · Accepted Answer

Pyruvate is decarboxylated by the E1 (pyruvate dehydrogenase) subunit of the PDH complex, which converts pyruvate to acetyl-CoA. The E2 subunit (dihydrolipoyl transacetylase) transfers the acetyl group to CoA to form acetyl-CoA, while the E3 subunit (dihydrolipoyl dehydrogenase) regenerates the oxidized form of lipoamide. The E4 and E5 subunits are regulatory proteins that modulate the activity of the PDH complex.

Pyruvate Is Decarboxylated by Which Subunit of the PDH