At which level(s) of protein structure are interactions between the side chains (R groups) most important?

Question

Quizplus · Accepted Answer

Interactions between the side chains (R groups) are most important at the tertiary level of protein structure. This is because the tertiary structure involves the folding and bending of the polypeptide chain into a specific 3D shape, which is stabilized by a variety of interactions between the R groups (such as van der Waals, hydrogen bonding, ionic interactions, and disulfide bonds). In the primary structure, the sequence of amino acids determines the overall structure of the protein, while the secondary structure involves local folding patterns stabilized by hydrogen bonding between backbone atoms. Quaternary structure involves the organization of multiple protein subunits, and side chain interactions are important in determining the overall shape and stability of the complex.

At Which Level(s) of Protein Structure Are Interactions Between the Side