Two eukaryotic proteins have one domain in common but are otherwise very different. Which of the following processes is most likely to have contributed to this similarity?

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Exon shuffling is the process by which exons from different genes are combined to form new genes. This can result in the creation of proteins with similar domains, but otherwise different sequences. Gene duplication can also result in similar domains, but the entire protein would be more similar. Alternative splicing can generate different isoforms of the same protein, but it would not result in similar domains between different proteins. Histone modification and random point mutations would not specifically lead to the creation of similar domains.

Two Eukaryotic Proteins Have One Domain in Common but Are