Let us suppose that someone is successful at producing induced pluripotent stem cells (iPS) for replacement of pancreatic insulin-producing cells for people with type 1 diabetes. Which of the following could still be problematic? I. the possibility that, once introduced into the patient, the iPS cells produce nonpancreatic cells
II) the failure of the iPS cells to take up residence in the pancreas
III) the inability of the iPS cells to respond to appropriate regulatory signals

Question

Quizplus · Accepted Answer

All of the given scenarios could still be problematic even if induced pluripotent stem cells (iPS) are successful in replacing pancreatic insulin-producing cells for people with type 1 diabetes. There is a possibility that the introduced iPS cells may produce nonpancreatic cells which could lead to undesired effects in the recipient. Even if the iPS cells reach the pancreas, they may fail to take up residence or respond to appropriate regulatory signals which can hinder the desired outcome of the therapy. Hence, all the scenarios mentioned in the options could challenge the efficacy and safety of the iPS cell therapy for type 1 diabetes.

Let Us Suppose That Someone Is Successful at Producing Induced