The side chain (R group) of the amino acid serine is -CH2-OH. The side chain of the amino acid leucine is -CH2-CH-(CH3)2. Where would you expect to find these amino acids in a globular protein in aqueous solution?

Question

Quizplus · Accepted Answer

The side chain of serine (-CH2-OH) is polar and can participate in hydrogen bonding with water molecules, making it favorable to be located on the exterior surface of a globular protein in aqueous solution. On the other hand, the side chain of leucine (-CH2-CH-(CH3)2) is nonpolar and would be buried in the hydrophobic interior of the protein, away from water molecules. Therefore, serine would be on the exterior, and leucine would be in the interior of the globular protein.

The Side Chain (R Group) of the Amino Acid Serine