Which of the following DNA mutations is likely to have the most negative effect on the protein it specifies?

Question

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A base-pair deletion would result in a frameshift mutation, where all codons downstream of the deletion would be shifted by one base, resulting in a completely different amino acid sequence after the mutation site. This would likely have the most negative effect on the protein's function. A codon substitution, substitution in the last base of a codon and a codon deletion could potentially have less negative effects, depending on the specific amino acid substitutions or deletions.

Which of the Following DNA Mutations Is Likely to Have