Which of the Following Statements Is Not True About Enzyme

Which of the following statements is not true about enzyme catalysis?

A) The reactant in an enzymatic reaction is called a substrate.
B) The lock-and-key model of enzyme catalysis relies on a perfect fit between enzyme and reactant to promote reaction.
C) The active site is the region of the protein that binds the reactant.
D) Inhibitors can bind only at the enzyme-active site to prevent reaction from occurring.
E) The induced fit model assumes that subtle changes mediated by reactant binding in the enzyme-active site lower the barrier for the desired reaction.