How is a viral antigen, like EBV, recognised by T cells?
A) An antigen fragment is presented within class I MHC to the T cell receptor.
B) Interferon proteins stick to the surface of infected cells.
C) T cells recognise antibodies that have bound to viral particles.
D) The virus is engulfed by T cells using Toll-like receptors.

Question

Quizplus · Accepted Answer

During viral infections, the infected host cells will process the viral antigens into small fragments and present them on the cell surface within the groove of class I MHC molecules. These antigen-MHC complexes will then be recognised by CD8+ T cells expressing a T cell receptor specific for that antigen. This leads to T cell activation and subsequent killing of the infected cell. EBV-specific CD8+ T cells can recognise and eliminate EBV-infected cells by recognising EBV antigenic peptides bound to class I MHC molecules on the surface of infected cells.

How Is a Viral Antigen, Like EBV, Recognised by T