Which of the following types of mutation would convert a proto-oncogene into an oncogene?
A) A mutation that blocks transcription of the proto-oncogene.
B) A mutation that creates an unstable proto-oncogene mRNA.
C) A mutation that greatly increases the amount of the proto-oncogene protein.
D) A deletion of most of the proto-oncogene coding sequence.

Question

Quizplus · Accepted Answer

A proto-oncogene becomes an oncogene when its protein product is overproduced or its signaling activity is increased due to a mutation. Option C describes a mutation that greatly increases the amount of the proto-oncogene protein, which can result in uncontrolled cell division and ultimately lead to cancer. Options A, B, and D are not likely to result in the conversion of a proto-oncogene into an oncogene.

Which of the Following Types of Mutation Would Convert a Proto-Oncogene