Why are BRCA1 and BRCA2 considered to be tumour-suppressor genes?
A) Their normal products participate in repair of DNA damage.
B) The mutant forms of either one of these prevent breast cancer.
C) The normal genes make oestrogen receptors.
D) They block penetration of breast cells by chemical carcinogens.

Question

Quizplus · Accepted Answer

BRCA1 and BRCA2 are considered to be tumor-suppressor genes because their normal products are involved in repairing DNA damage, specifically double-strand breaks. Mutations in these genes can impair their ability to repair DNA damage, leading to genetic instability and an increased risk of developing certain cancers, including breast and ovarian cancer. Mutations in these genes do not prevent breast cancer, nor do they make oestrogen receptors or block penetration of breast cells by chemical carcinogens.

Why Are BRCA1 and BRCA2 Considered to Be Tumour-Suppressor Genes