According to the dose-response principle,

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The dose-response principle states that the higher the dosage of a drug, the more severe the damage will be to the developing fetus. This means that exposure to high levels of drugs, alcohol or other toxins during pregnancy can have a more negative impact on the developing fetus than exposure to lower levels. It is important for pregnant women to avoid exposure to harmful substances and to receive proper medical care throughout pregnancy.

According to the Dose-Response Principle