The sickle-cell trait is said to have had survival value because it is associated with

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The sickle-cell trait is known to confer resistance against malarial infection because the shape of the sickled red blood cells impairs the ability of the malaria parasite to invade and replicate within the erythrocytes. Therefore, individuals who carry the sickle-cell trait are less likely to be infected with malaria and more likely to survive in regions where malaria is prevalent.

The Sickle-Cell Trait Is Said to Have Had Survival Value