A Client Reports Taking Acetaminophen (Tylenol)to Control Osteoarthritis

A client reports taking acetaminophen (Tylenol) to control osteoarthritis.Which instruction should the nurse give the patient requiring long-term acetaminophen use?

A) Caution the patient against combining acetaminophen with alcohol.
B) Explain that acetaminophen increases the risk for bleeding.
C) Advise taking acetaminophen with meals to prevent gastric irritation.
D) Explain that physical dependence may occur with long-term oral use.