Analysis of a newborn's cord blood specimen following Coombs' direct antiglobulin testing (DAT)indicates red blood cell (RBC)agglutination of 3+.However, the health-care provider is concerned that the result may be a false positive.Which of the following factors could lead to a false positive? Select all that apply.
A)ABO hemolytic disease
B)Acetaminophen use
C)Presence of Wharton's jelly in the specimen
D)Use of a tube method for DAT
E)Presence of cold agglutinins in the specimen

Question

Quizplus · Accepted Answer

B) Acetaminophen use can cause a false positive result in Coombs' direct antiglobulin testing (DAT).
C) Presence of Wharton's jelly in the specimen can interfere with the testing process and lead to a false positive result.
E) Presence of cold agglutinins in the specimen can cause agglutination of red blood cells, leading to a false positive result in DAT. ABO hemolytic disease and use of a tube method for DAT do not typically result in false positive results.

Analysis of a Newborn's Cord Blood Specimen Following Coombs' Direct