A patient is suspected of having Graves' disease.Which test would be most appropriate for confirming this suspicion?
A)Thyroglobulin
B)Thyroid-binding inhibitory immunoglobulin
C)Thyroxine-binding globulin
D)Toxoplasma antibody

Question

Quizplus · Accepted Answer

The most appropriate test for confirming Graves' disease is the measurement of thyroid-binding inhibitory immunoglobulin (TBI or TBII). This is an autoantibody that binds to and activates the TSH receptor on thyroid cells, leading to increased thyroid hormone production and release. Elevated TBI levels are specific for Graves' disease and help distinguish it from other causes of hyperthyroidism. Thyroglobulin is a protein produced by the thyroid gland and is useful in monitoring patients with thyroid cancer. Thyroxine-binding globulin (TBG) is a protein that binds to thyroid hormones and transports them in the blood, but elevated levels of TBG do not indicate Graves' disease. Toxoplasma antibody testing is used to detect previous exposure to Toxoplasma gondii, a parasite that causes toxoplasmosis, and is not relevant for the diagnosis of Graves' disease.

A Patient Is Suspected of Having Graves' Disease