Which of the following guidelines should be considered when determining the need for locally delivered antimicrobials? Select all that apply.

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Locally delivered antimicrobials are often considered for pockets equal to or greater than 5 mm (A) because these areas may not respond adequately to conventional mechanical debridement alone. Areas not responding to debridement (B) are also candidates for locally delivered antimicrobials as an adjunctive treatment to help control the bacterial load. Patients who are poor surgical candidates (D) may benefit from locally delivered antimicrobials as an alternative to surgical intervention, especially when surgery is not an option due to medical or other reasons. However, the choice of treatment should not be based solely on the patient's oral self-care practices (C), as the primary consideration should be the clinical condition and the specific characteristics of the periodontal disease.

Which of the Following Guidelines Should Be Considered When Determining