What is the largest possible value that linkage disequilibrium can reach if all allele frequencies are 0.5?
A) 0.25
B) 0.5
C) 0.75
D) 1

Question

Quizplus · Accepted Answer

Linkage disequilibrium (D) is maximized when one of the haplotypes (combinations of alleles at different loci) is absent, leading to D = pA pB - pAB = (0.5)(0.5) - 0 = 0.25, where pA and pB are the allele frequencies (both 0.5 in this case) and pAB is the frequency of the haplotype combining both alleles A and B (0 in the case of maximum disequilibrium).

What Is the Largest Possible Value That Linkage Disequilibrium Can