Which of the following have the S configuration?

Question

Quizplus · Accepted Answer

To determine the configuration (R or S) of chiral centers, we need to assign priorities to the groups attached to them based on their atomic numbers.

For compound 1, the priority order is: Cl > Br > CH3 > H. When we draw a circle from the lowest priority group (H) to the highest (Cl), we find that the molecule is oriented clockwise, which means it has an S configuration.

For compound 2, the priority order is: OH > Br > CH3 > H. Again, when we draw a circle from the lowest to the highest priority group, we find that the molecule is oriented clockwise, which means it has an S configuration.

For compound 3, the priority order is: Cl > F > C2H5 > H. However, when we draw a circle from the lowest to the highest priority group, we find that the molecule is oriented counterclockwise, which means it has an R configuration.

Therefore, only compounds 1 and 2 have the S configuration.

Which of the Following Have the S Configuration