The interior of a neuron that is carrying a nerve impulse has more sodium ions in it than the interior of a neuron that isn't carrying a nerve impulse.

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During a nerve impulse, sodium ions rush into the neuron, causing the interior of the neuron to become more positively charged. This depolarization allows the impulse to continue traveling along the neuron. When the impulse is not occurring, the sodium ions are actively pumped out of the neuron, causing the interior to become more negatively charged.

The Interior of a Neuron That Is Carrying a Nerve