If internal respiration is working properly, the blood leaving the tissues will have less oxyhemoglobin and more carbaminohemoglobin than the blood entering the tissues.

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During internal respiration, oxygen is released from oxyhemoglobin and carbon dioxide is bound to hemoglobin to form carbaminohemoglobin. This means that the blood leaving the tissues will have a higher concentration of carbaminohemoglobin and a lower concentration of oxyhemoglobin than the blood entering the tissues.

If Internal Respiration Is Working Properly, the Blood Leaving the Tissues