Swyer syndrome (46, XY, female appearance), would most likely result from

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Swyer syndrome is characterized by individuals who are phenotypically female but have a 46,XY karyotype. This condition is not caused by nondisjunction (which would affect the number of chromosomes), but rather by a mutation or deletion in the Y chromosome, specifically affecting the SRY gene, which is crucial for male sex determination. This deletion prevents the development of male physical characteristics, leading to a female phenotype despite the presence of a Y chromosome.

Swyer Syndrome (46, XY, Female Appearance), Would Most Likely Result