Cognitive-behavioral therapy works, top-down, by changing thought processes. Antidepressant drugs work, bottom-up, on the emotion-forming

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Antidepressant drugs work on the emotion-forming limbic system. This is the area of the brain responsible for emotion regulation and plays a key role in depression. Cognitive-behavioral therapy, on the other hand, works on changing thought processes, which involves higher-order brain functions.

Cognitive-Behavioral Therapy Works, Top-Down, by Changing Thought Processes