Which of the following has been shown to cause muscle fatigue? A)the accumulation H⁺ B)the accumulation of ATP C)the accumulation of inorganic phosphate D)both A and C are correct

Question

Quizplus · Accepted Answer

The accumulation of inorganic phosphate (Pi) has been shown to interfere with the release of Ca2+ from the sarcoplasmic reticulum and reduce the sensitivity of the contractile proteins to Ca2+, leading to muscle fatigue. Similarly, the accumulation of H⁺ (lactic acid and its conjugate base lactate) has been shown to cause muscle fatigue by disrupting pH balance and reducing muscle contractility. ATP is necessary for muscle contraction and its accumulation is unlikely to cause fatigue.

Which of the Following Has Been Shown to Cause Muscle