Which of the Following Statements Concerning Enzyme Active Sites Is

Which of the following statements concerning enzyme active sites is incorrect?

A) They generally involve only a small portion of the enzyme.
B) Noncompetitive inhibitors can change active site shape.
C) The lock-and-key model of enzyme activity assumes that an active site has a fixed, rigid geometrical conformation.
D) More than one correct response.
E) No correct response.