What would be the result of a mutation in Hsp90 that prevented its binding to the glucocorticoid receptor?
A) Glucocorticoid receptor could not form a dimer
B) The nuclear localization signal would no longer function
C) Expression of the regulated genes would become constitutive
D) The hormone would not be able to bind to the glucocorticoid receptor

Question

Quizplus · Accepted Answer

Hsp90 is a chaperone protein that plays a crucial role in stabilizing and activating the glucocorticoid receptor. Without Hsp90 binding, the glucocorticoid receptor would not be able to fold correctly and function properly. This would result in a loss of regulation, causing the expression of the regulated genes to become constitutive. The other options are not directly related to the functioning of Hsp90 with the glucocorticoid receptor.

What Would Be the Result of a Mutation in Hsp90