A mutation in TFIIIE could result in
A) a failure of the RNA polymerase to bind to TFIIB
B) a failure of the RNA polymerase to maintain an closed complex
C) a failure of the RNA polymerase to maintain an open complex
D) no effect on transcription

Question

Quizplus · Accepted Answer

TFIIIE is responsible for maintaining an open complex during transcription, which is essential for RNA polymerase to initiate elongation. Therefore, a mutation in TFIIIE could result in a failure of the RNA polymerase to maintain an open complex, leading to transcriptional failure.

A Mutation in TFIIIE Could Result in