What structural motif is most commonly used by transcription factors in binding to DNA?
A) Zinc-finger
B) Helix-turn-helix
C) Leucine zipper
D) Homeodomain

Question

Quizplus · Accepted Answer

The helix-turn-helix motif is the most commonly used structural motif by transcription factors in binding to DNA. It consists of two α-helices separated by a turn, with the first helix inserting into the major groove of DNA to provide sequence specificity. Zinc fingers, leucine zipper, and homeodomain motifs can also be used for DNA binding, but they are less commonly used.

What Structural Motif Is Most Commonly Used by Transcription Factors