You are examining the following human pedigree and want to determine if the rare dominant disease allele (D)is linked to a specific DNA sequence location, referred to as a "molecular marker." You are using two molecular markers, R1 and R2.Parental and progeny genotypes and phenotypes are indicated.Note that the father is a dihybrid at both loci, but the mother is homozygous recessive at both loci and linked to R1 (d-R1/d-R1).There is complete penetrance of the trait and a linkage phase of D-R1/d-R2 in the father.Assuming that the marker and the gene are linked, what is the best estimate of the map distance between the two loci?
A)12 cM
B)50 cM
C)16 cM
D)5 cM
E)25 cM

Question

You are examining the following human pedigree and want to determine if the rare dominant disease allele (D)is linked to a specific DNA sequence location, referred to as a "molecular marker." You are using two molecular markers, R1 and R2.Parental and progeny genotypes and phenotypes are indicated.Note that the father is a dihybrid at both loci, but the mother is homozygous recessive at both loci and linked to R1 (d-R1/d-R1).There is complete penetrance of the trait and a linkage phase of D-R1/d-R2 in the father.Assuming that the marker and the gene are linked, what is the best estimate of the map distance between the two loci? 
A)12 cM 
B)50 cM 
C)16 cM 
D)5 cM 
E)25 cM

Quizplus · Accepted Answer

The Answer of You are examining the following human pedigree and want to determine if the rare dominant disease allele (D)is linked to a specific DNA sequence location, referred to as a "molecular marker." You are using two molecular markers, R1 and R2.Parental and progeny genotypes and phenotypes are indicated.Note that the father is a dihybrid at both loci, but the mother is homozygous recessive at both loci and linked to R1 (d-R1/d-R1).There is complete penetrance of the trait and a linkage phase of D-R1/d-R2 in the father.Assuming that the marker and the gene are linked, what is the best estimate of the map distance between the two loci? 
A)12 cM 
B)50 cM 
C)16 cM 
D)5 cM 
E)25 cM

You Are Examining the Following Human Pedigree and Want to Determine