For most protein-coding genes, the rate of substitution in _____ is considerably higher than in _____.

Name: For most protein-coding genes, the rate of substitution in _____ is considerably higher than in _____.
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The rate of substitution is higher in synonymous sites because these do not change the amino acid sequence of the protein, and thus are less subject to selective pressure compared to nonsynonymous sites, which do affect the protein sequence and are more likely to be deleterious.

For Most Protein-Coding Genes, the Rate of Substitution in _____