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In Burkitt Lymphoma Patients, Despite Translocation, the Oncogene C-MYC Remains

Question 64

Multiple Choice

In Burkitt lymphoma patients, despite translocation, the oncogene c-MYC remains nearly intact in its new location. Yet c-MYC is believed to be responsible for the lymphoma because the c-MYC:


A) DNA sequence undergoes hypermethylation
B) DNA sequence is nearly intact but is inverted in the new position
C) gene is released from inhibition by miRNAs
D) gene is placed under the control of B-cell-specific gene regulatory sequences and is highly expressed
E) DNA sequence undergoes several point mutations

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