Which of the following sequence of events will likely lead to colorectal cancer?
A) Carcinoma develops, polyps form, cancer metastasizes.
B) Adenoma forms, polyps form, tumor-suppressor APC gene mutates, cancer metastasizes.
C) Tumor-suppressor APC gene mutates, polyps form, adenoma forms, carcinoma forms.
D) Proto-oncogenes mutate into tumor-suppressor genes, polyps form, cancer metastasizes.
E) Carcinoma becomes metastatic, polyps form, tumor-suppressor APC gene mutates.
Correct Answer:
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