Suppose a research study shows that people who suffer from severe depression are homozygous for a mutation in the hypothetical DEP gene.Individuals without this form of depression have the following sequence at the beginning of the translated region of their DEP genes 5'-ATG ACG TTT GAA ATT CAG TCT AGA-3'(MET THR PHE GLU ILE GLN SER ARG).Affected individuals have the following sequence 5'-ATG ACG TTT GAA ATT TAG TCT AGA-3'(MET THR PHE GLU ILE STOP).The mutation identified is most likely a:

Question

Quizplus · Accepted Answer

The change from "CAA" (glutamine) to "TAA" (stop codon) in the affected individuals represents a nonsense mutation, as it causes premature termination of protein synthesis. This mutation results in a truncated and likely non-functional DEP protein, which could contribute to the development of severe depression.

Suppose a Research Study Shows That People Who Suffer from Severe