Once a chromosomal position for a putative gene associated with Parkinson disease is verified, which of the following is a next step?
A)developing a FISH screening test to identify pre-Parkinson patients
B)determining whether this locus is mutated in all Parkinson patients
C)using a genome-wide linkage SNP panel to identify more minor genes
D)ascertaining all living and at-risk individuals who are family members of the affected test subjects
E)fine mapping of the linkage region to identify particular variants for influencing risk

Question

Quizplus · Accepted Answer

Fine mapping of the linkage region would involve narrowing down the specific variants in the region that may be influencing Parkinson disease risk. This would be a logical next step after identifying the chromosomal position of the putative gene. The other options listed may be important steps in the overall process of identifying a genetic cause of Parkinson disease, but they are not necessarily the next step after verifying a chromosomal position.

Once a Chromosomal Position for a Putative Gene Associated with Parkinson