Which type of sequencing involves first creating a physical map?

Question

Quizplus · Accepted Answer

Clone-by-clone sequencing involves first creating a physical map of the genome by breaking it down into large pieces and then creating a map of the overlapping regions. This is in contrast to whole-genome shotgun sequencing, which involves breaking the genome into small pieces randomly and then piecing them back together using computational algorithms. Paired-end sequencing and metagenomic sequencing are both types of sequencing strategies that can be used in either clone-by-clone or whole-genome shotgun sequencing. Annotation sequencing is not a type of sequencing, but rather refers to the process of adding functional information to the genetic sequences that have already been determined through a sequencing project.

Which Type of Sequencing Involves First Creating a Physical Map