Prader-Willi and Angelman syndromes are caused by which type of chromosomal mutations, both in connection with chromosome 15?
A)monosomy
B)trisomy
C)mosaicism
D)uniparental disomy
E)random X-inactivation

Question

Quizplus · Accepted Answer

Both Prader-Willi and Angelman syndromes are caused by a loss of function of genes on chromosome 15. In the case of Prader-Willi, this is due to a lack of expression of paternal genes on chromosome 15, while in the case of Angelman syndrome, there is a lack of expression of maternal genes on the same chromosome. This can occur due to a phenomenon called uniparental disomy, which is the inheritance of both copies of a chromosome from one parent, rather than one copy of the chromosome from each parent. This is the result of a chromosomal mutation.

Prader-Willi and Angelman Syndromes Are Caused by Which Type of Chromosomal