What is required for DNA polymerase to initiate DNA strand synthesis?
A)a short DNA primer synthesized by the enzyme primase
B)a short RNA primer synthesized by the enzyme primase
C)ATP and a short DNA primer synthesized by the enzyme topoisomerase
D)ATP and a short RNA primer synthesized by the enzyme topoisomerase
E)DNA polymerase initiates DNA strand synthesis without requiring any additional enzymes.

Question

Quizplus · Accepted Answer

DNA polymerase cannot initiate DNA strand synthesis on its own, it requires a short RNA primer synthesized by the enzyme primase. The RNA primer provides a 3'-OH group for DNA polymerase to begin adding nucleotides in the 5' to 3' direction.

What Is Required for DNA Polymerase to Initiate DNA Strand