Mutations that inhibit Rb gene expression will have what effect on cell proliferation?
A)Cells will proliferate less, even if excess growth factors are present.
B)Cells will proliferate less because growth factors are absent.
C)Cells will proliferate more because growth factors are produced in excess.
D)Cells will proliferate more, regardless of growth factor concentration.
E)There will be no effect on cell proliferation; only apoptosis occurs.

Question

Quizplus · Accepted Answer

Mutations that inhibit Rb gene expression will lead to increased cell proliferation, regardless of growth factor concentration. This is because Rb normally acts as a tumor suppressor by inhibiting the activity of E2F transcription factors that promote cell cycle progression. When Rb is inhibited by a mutation, E2F activity increases, promoting cell proliferation. Therefore, cells will continue to proliferate even if excess growth factors are not present.

Mutations That Inhibit Rb Gene Expression Will Have What Effect