When Creating Transgenic Animals,as Contrasted with the Creation of Transgenic

When creating transgenic animals,as contrasted with the creation of transgenic bacteria,

A) it is necessary to carry out the procedure completely by hand.
B) animals need donor eggs to contain the genetic material,while bacteria can have the new genes inserted into any bacterial cell.
C) transgenic animals can be created in large numbers,while bacteria must be created one at a time to control contamination.
D) the membranes of the bacteria must be disrupted to allow the genes to be taken up into the cell and animals do not require the host cell membrane to be disrupted.
E) the membranes of the animal cell must be disrupted to allow the genes to be taken up into the cell and bacteria do not require the host cell membrane to be disrupted.