Huntington disease is an autosomal dominant disorder that leads to progressive degeneration of brain cells.There is no effective treatment for the disorder and individuals usually die in their 40s or 50s,10 to 15 years after the onset of symptoms.Which of these statements about Huntington disease is true?
A)As an autosomal dominant disease,Huntington disease is expressed only if both parents carry the trait.
B)Huntington disease usually skips a generation.
C)Huntington disease can only be inherited when a parent is showing the trait.
D)Huntington disease usually appears during middle age.
E)Huntington disease is caused by a defect in the elastic connective tissue protein.

Question

Quizplus · Accepted Answer

Huntington disease usually appears during middle age, around 30 to 50 years old. Option A is incorrect because as an autosomal dominant disorder, only one copy of the mutated gene is required to develop the disease, regardless of whether one or both parents are carriers. Option B is incorrect because there is no evidence that Huntington disease skips a generation. Option C is incorrect because carriers of the Huntington disease gene may not display symptoms, but can still pass on the gene to their children. Option E is incorrect because Huntington disease is caused by a mutation in the huntingtin gene, which codes for a protein that plays a role in brain cell function.

Huntington Disease Is an Autosomal Dominant Disorder That Leads to Progressive