What is the effect of a high P₅₀?

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Quizplus · Accepted Answer

A high P₅₀ means hemoglobin's affinity for oxygen is decreased. Similarly, a low P₅₀ means hemoglobin's affinity for oxygen is increased, causing it to bind oxygen molecules more aggressively (i.e., in this situation, hemoglobin is more than 50% saturated with oxygen at a PO₂ of 27 mm Hg). In the alveoli where oxygen loading takes place, blood with a low P₅₀ (high oxygen affinity) is advantageous. Conversely, high hemoglobin affinity for oxygen is detrimental at the tissue level where oxygen release is required. Ideally, hemoglobin affinity for oxygen changes depending on whether loading or unloading is required.

What Is the Effect of a High P50

What Is the Effect of a High P₅₀