Lithium,valproic acid,and lamotrigine are all known to _____ GSK-3 levels,and _____ b-catenin levels.

Question

Quizplus · Accepted Answer

Lithium, valproic acid, and lamotrigine are known to decrease GSK-3 levels, which leads to an increase in beta-catenin levels. This is because GSK-3 normally phosphorylates beta-catenin, which targets it for degradation. By inhibiting GSK-3, these drugs allow beta-catenin to accumulate in the cell.

Lithium,valproic Acid,and Lamotrigine Are All Known to _____ GSK-3 Levels,and