In morphine-dependent subjects,administration of a mixed agonist-antagonist:
A)produces effects similar to morphine.
B)produces no effects.
C)induces withdrawal.
D)produces effects similar to,but is weaker than,morphine.

Question

Quizplus · Accepted Answer

Administration of a mixed agonist-antagonist in morphine-dependent subjects induces withdrawal because mixed agonist-antagonists have partial agonist properties that can displace full agonists like morphine from opiate receptors in the brain, thereby reducing the effects of morphine and inducing withdrawal symptoms.

In Morphine-Dependent Subjects,administration of a Mixed Agonist-Antagonist