Paul has become addicted to heroin; probably the most well-established pharmacological intervention for his addiction is:

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Agonist substitution treatments, such as methadone or buprenorphine, are currently the most well-established pharmacological interventions for heroin addiction. These medications act as replacement opioids to stabilize the person's physical dependence and reduce cravings, allowing for a more controlled withdrawal process and an increased likelihood of success in recovery. Antagonists, such as naltrexone, can also be effective but are more commonly used as a maintenance treatment after initial detoxification. Partial agonist substitution treatments, such as suboxone, may also be used but are considered less effective than full agonist substitution treatments. Targeting nondopaminergic neurotransmitter systems is still an area of ongoing research and has not yet been established as a primary intervention for heroin addiction.

Paul Has Become Addicted to Heroin; Probably the Most Well-Established