Probably the most well-established pharmacological intervention for opioid and nicotine addiction is:

Name: Probably the most well-established pharmacological intervention for opioid and nicotine addiction is:
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Agonist substitution treatments, such as methadone and nicotine replacement therapy, have been shown to be effective in treating opioid and nicotine addiction by targeting the same receptors as the addictive substance, but in a safer and controlled way, reducing withdrawal symptoms and cravings.

Probably the Most Well-Established Pharmacological Intervention for Opioid and Nicotine